| Pair Name | Menadione, Ascorbic Acid | ||
| Phytochemical Name | Menadione (PubChem CID: 4055 ) | ||
| Anticancer drug Name | Ascorbic Acid (PubChem CID: 54670067 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Menadione, Ascorbic Acid | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| Gene Regulation | Down-regulation | Expression | BECN1 | hsa8678 |
| Up-regulation | Activity | BECN1 | hsa8678 | |
| Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
| Down-regulation | Expression | RHEB | hsa6009 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| Up-regulation | Phosphorylation | ULK1 | hsa8408 | |
| In Vitro Model | U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 |
| Result | These results suggest that AA+MD or MD treatment in combination with autophagy inducers could be further investigated as a novel approach for glioblastoma therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells. Oxid Med Cell Longev. 2022 Mar 23;2022:2998132. doi: 10.1155/2022/2998132. | Click |
